Potential impurity in ranitidine formulations

Medicines containing ranitidine have been recalled by some overseas regulatory authorities because of nitrosamine contamination. Nitrosamine is potentially carcinogenic. Medsafe have taken a more conservative approach and not yet made any recalls. However, GlaxoSmithKline (NZ) Ltd has issued a medicine level recall (pharmacy level only) effective 30/9/19 of all Zantac Injection 50mg/2mL and put a halt on further supply until further information is available.

Please see Medsafe’s alert for guidance: https://www.medsafe.govt.nz/safety/Alerts/MedicinesAndNDMA.asp.