Discontinuation of the combination product cilazapril with hydrochlorothiazide tablets

Apo-Cilazapril/Hydrochlorothiazide® has been discontinued and supply in NZ is expected to run out by July 2020. We recommend all patients taking this product be reviewed and changed to an alternative treatment. From 1st March, prescriptions for existing patients will need to be annotated for funding. See PHARMAC guidance for more details.

Cilazapril tablets are still available and hydrochlorthiazide is available in combination with quinapril.

Note: cilazapril is not used widely overseas and there is potential for supply issues in the future. It is suggested to consider the fully funded long-acting ACE inhibitors, enalapril, perindopril and lisinopril, which are used widely internationally. 

Hydrochlorthiazide has a shorter half-life and weaker evidence base than other widely available thiazide diuretics. It is recommended to consider the fully funded long-acting thiazide diuretics, chlortalidone, bendroflumethiazide and indapamide.

See Health Pathways and BPAC guidance for advice on management, or contact the Christchurch Medicines Information Service for advice on specific patients.