Bulletins - Other
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Analgesia during pregnancy or while breastfeeding - July 5, 2023
Treatment of pain in pregnant and breastfeeding women should follow the same principles as for all adults, using the analgesic ladder:
Step 1: Paracetamol and/ or NSAID, e.g. ibuprofen or diclofenac
Step 2: Add a weak opioid for mild to moderate pain, e.g. codeine, tramadol
Step 3: Chang...



Crushing nirmatrelvir+ritonavir (Paxlovid®) tablets - December 22, 2022
Background
Pfizer state in their prescribing information that both nirmatrelvir and ritonavir tablets should be swallowed whole and not chewed, broken, or crushed. [1] This is due to a lack of pharmacokinetic data to support administration in this manner. However, a Phase 1 study with a nirmatre...



Pharmacokinetic medicines interactions with probenecid - November 29, 2022
Probenecid was introduced in the 1950’s to reduce the renal elimination and extend the plasma half-life of penicillins. This effect is exploited therapeutically in the treatment of cellulitis and other infections. It is also used for gout prophylaxis, in light of its uricosuric effects.
Prob...



Morphine and Oxycodone – Similarities and Differences - August 17, 2022
Note this bulletin is older than 5 years old and the content may no longer be accurate



Prescribing in Patients with Frailty - August 17, 2022
Note this bulletin is older than 5 years old and the content may no longer be accurate



Herb Drug Interactions - August 17, 2022
Note this bulletin is older than 5 years old and the content may no longer be accurate



Medication Induced Hyponatraemia - August 17, 2022
Note this bulletin is older than 5 years old and the content may no longer be accurate



Drug Interactions with Statins - August 17, 2022
Note this bulletin is older than 5 years old and the content may no longer be accurate