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Probenecid to extend the plasma half-life of beta-lactam antibiotics - February 1, 2013
Probenecid was introduced in the 1950’s to reduce the renal elimination and extend the plasma half-life of penicillins. This effect is exploited therapeutically in the treatment of cellulitis and other infections. This bulletin will focus on the use of probenecid to extend the plasma half-life ...