Aminoglycosides (gentamicin, tobramycin and amikacin) are bactericidal antibiotics used to treat infections caused by Gram-negative organisms. Therapeutic drug monitoring is recommended to ensure adequate dosing and prevent adverse effects such as nephrotoxicity and ototoxicity. Aminoglycosides demonstrate concentration-dependent bactericidal activity, which is optimal when the maximum concentration (Cmax) is ≥ 10 times the minimum inhibitory concentration … Continue reading Therapeutic Drug Monitoring of Aminoglycosides