Christchurch Medicines Information Service

Treatment of pain in pregnant and breastfeeding women should follow the same principles as for all adults, using the analgesic ladder: Step 1: Paracetamol and/ or NSAID, e.g. ibuprofen or diclofenac Step 2: Add a weak opioid for mild to moderate pain, e.g. codeine, tramadol Step 3: Chang...

Sometimes it is necessary to give a lower patch dose than is available. This problem has become more frequent with supply issues for some patch doses. Manipulation of a dose form can affect pharmacokinetics and stability, although there are very few studies involving patches. Cutting or occluding...

Depression affects approximately 10% of pregnant people and is associated with adverse parental and foetal outcomes, including compromised parenting, which can impact on child development.(1) Some data suggest that antidepressants may increase the risk of spontaneous abortion, preterm delivery an...

Nausea, with or without vomiting, is common in pregnancy, affecting up to 80% of women. Symptoms usually begin between four and seven weeks, peak at nine weeks, and resolve by 16 to 20 weeks. Up to 2% of women develop hyperemesis gravidarum, where persistent vomiting may lead to dehydration, weig...

Background Pfizer state in their prescribing information that both nirmatrelvir and ritonavir tablets should be swallowed whole and not chewed, broken, or crushed. [1] This is due to a lack of pharmacokinetic data to support administration in this manner. However, a Phase 1 study with a nirmatre...

Probenecid was introduced in the 1950’s to reduce the renal elimination and extend the plasma half-life of penicillins. This effect is exploited therapeutically in the treatment of cellulitis and other infections. It is also used for gout prophylaxis, in light of its uricosuric effects. Prob...

  Key points: There is far less information about how well complementary and alternative products work and how safe they are compared to medicines. There are no rules in Aotearoa NZ to make sure the contents are what the label says. This makes it difficult to say whether the...

Note this bulletin is older than 5 years old and the content may no longer be accurate

Note this bulletin is older than 5 years old and the content may no longer be accurate

Note this bulletin is older than 5 years old and the content may no longer be accurate